GPS1

From Wikipedia, the free encyclopedia

G protein pathway suppressor 1

Identifiers

GPS1; CSN1; COPS1; MGC71287

External IDs

OMIM: 601934 MGI: 2384801 HomoloGene: 3046

Gene ontology
Molecular Function:	• GTPase inhibitor activity
Cellular Component:	• nucleus • signalosome
Biological Process:	• inactivation of MAPK activity • cell cycle • JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004127 (mRNA)
NP_004118 (protein)

XM_001002541 (mRNA)
XP_001002541 (protein)

Location

Chr 17: 77.6 - 77.61 Mb

Chr 11: 120.6 - 120.61 Mb

Pubmed search

[1]

[2]

G protein pathway suppressor 1, also known as GPS1, is a human gene.^[1]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GPS1 G protein pathway suppressor 1.

[edit] Further reading

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029-33. doi:10.1038/ncb1203-1029. PMID 14647295.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Spain BH, Bowdish KS, Pacal AR, et al. (1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.". Mol. Cell. Biol. 16 (12): 6698-706. PMID 8943324.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Seeger M, Kraft R, Ferrell K, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.". FASEB J. 12 (6): 469-78. PMID 9535219.
Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.". Curr. Biol. 8 (16): 919-22. PMID 9707402.
Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.". J. Mol. Biol. 305 (1): 1-9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.". EMBO J. 20 (7): 1630-9. doi:10.1093/emboj/20.7.1630. PMID 11285227.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382-5. doi:10.1126/science.1059780. PMID 11337588.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome.". FEBS Lett. 527 (1-3): 15-21. PMID 12220626.
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.". J. Biol. Chem. 277 (48): 45759-64. doi:10.1074/jbc.M208709200. PMID 12324474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Serino G, Su H, Peng Z, et al. (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex.". Plant Cell 15 (3): 719-31. PMID 12615944.
Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.". EMBO J. 22 (6): 1302-12. doi:10.1093/emboj/cdg127. PMID 12628923.
Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.". Cell 113 (3): 357-67. PMID 12732143.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Wang Y, Lu C, Wei H, et al. (2004). "Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity.". FEBS Lett. 572 (1-3): 85-91. doi:10.1016/j.febslet.2004.07.012. PMID 15304329.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.