Talk:Goldenseal

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why is its efficacy unknown? Somebody do a test! - ShadowyCabal 11:38, 6 September 2006 (UTC)

Contents 1 citing sources 2 toxicity 3 Warnings 4 Article Substantially Rewritten 5 Berberine

[edit] citing sources

There are many statements here that need specific references to particular studies or effects, please add them if you know the correct study for the source. thanks

[edit] toxicity

The toxicity information is not accurate and requires reference. And the idea that it should be taken once a day is silly. Goldenseal should be used with care- I reserve it for pneumonia and diseases of the mucosa where it has an affinity. But it can be dosed throughout the day. KSVaughan 20:47, 11 May 2007 (UTC)

And elsewhere it said it could be taken as a vitamin or to recover from exercise. I removed that which is erroneous as this is not an adaptogen or even a food grade herb. Karen S Vaughan 04:45, 15 May 2007 (UTC)

[edit] Warnings

This section contains information antithetical to the research cited as far as toxicity. I find no mention of any Hotaki study in Medline or Medscape, and if in vitro studies did show a reduction in sperm count it would only mean that you shouldn't put sperm in a testtube with goldenseal before implanting them. I am removing the section. Karen S Vaughan 01:22, 14 May 2007 (UTC)

The information on toxicity and LD50 of berberine are incorrect. Berberine chloride was used at 15mg/kg in rats with colitis and decreased intestinal inflammation, I don't think a dose of 27mg/kg would be lethal in humans.

The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro Haiyan Zhou and Satoru Mineshita 202.28.62.245 (talk) 05:52, 11 December 2007 (UTC)David Hammond

[edit] Article Substantially Rewritten

The article has been substantially rewritten. Karen S Vaughan 16:48, 15 May 2007 (UTC)

[edit] Berberine

Added links and backlinks to Berberine as they are deeply interesting and interelated pharmacological discussions going on here. Cheers,122.148.173.37 22:19, 2 December 2007 (UTC)