GOLGA1

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Golgi autoantigen, golgin subfamily a, 1
Identifiers
Symbol(s) GOLGA1; MGC33154; golgin-97
External IDs OMIM: 602502 MGI: 1924149 HomoloGene: 68223
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2800 76899
Ensembl ENSG00000136935 ENSMUSG00000026754
Uniprot Q92805 Q05CJ8
Refseq NM_002077 (mRNA)
NP_002068 (protein)		 NM_029793 (mRNA)
NP_084069 (protein)
Location Chr 9: 126.68 - 126.74 Mb Chr 2: 38.84 - 38.89 Mb
Pubmed search [1] [2]

Golgi autoantigen, golgin subfamily a, 1, also known as GOLGA1, is a human gene.[1]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome.[1]

[edit] References

  1. ^ a b Entrez Gene: GOLGA1 golgi autoantigen, golgin subfamily a, 1.

[edit] Further reading

  • Griffith KJ, Chan EK, Lung CC, et al. (1997). "Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome.". Arthritis Rheum. 40 (9): 1693-702. doi:10.1002/1529-0131(199709)40:9<1693::AID-ART20>3.0.CO;2-6. PMID 9324025. 
  • Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins.". Curr. Biol. 9 (7): 381-4. PMID 10209123. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.". Mol. Biol. Cell 14 (9): 3767-81. doi:10.1091/mbc.E03-01-0864. PMID 12972563. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Lu L, Tai G, Hong W (2005). "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.". Mol. Biol. Cell 15 (10): 4426-43. doi:10.1091/mbc.E03-12-0872. PMID 15269279. 
  • Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.". Biochem. J. 388 (Pt 3): 835-41. doi:10.1042/BJ20041810. PMID 15654769. 
  • Lock JG, Hammond LA, Houghton F, et al. (2006). "E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97.". Traffic 6 (12): 1142-56. doi:10.1111/j.1600-0854.2005.00349.x. PMID 16262725. 
  • Alzhanova D, Hruby DE (2007). "A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.". Virology 362 (2): 421-7. doi:10.1016/j.virol.2007.01.003. PMID 17276477. 
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