GNL3

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein-like 3 (nucleolar)

Identifiers

GNL3; NS; C77032; E2IG3; MGC800

External IDs

OMIM: 608011 MGI: 1353651 HomoloGene: 56670

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • GTP binding
Cellular Component:	• intracellular • nucleus • nucleolus
Biological Process:	• regulation of progression through cell cycle • regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014366 (mRNA)
NP_055181 (protein)

NM_153547 (mRNA)
NP_705775 (protein)

Location

Chr 3: 52.7 - 52.7 Mb

Chr 14: 29.84 - 29.85 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein-like 3 (nucleolar), also known as GNL3, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar).

[edit] Further reading

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Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Tsai RY, McKay RD (2003). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMID 12464630.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Schwartz PH, Bryant PJ, Fuja TJ, et al. (2004). "Isolation and characterization of neural progenitor cells from post-mortem human cortex.". J. Neurosci. Res. 74 (6): 838–51. doi:10.1002/jnr.10854. PMID 14648588.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu SJ, Cai ZW, Liu YJ, et al. (2004). "Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies.". World J. Gastroenterol. 10 (9): 1246–9. PMID 15112336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sijin L, Ziwei C, Yajun L, et al. (2005). "The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells.". J. Exp. Clin. Cancer Res. 23 (3): 529–38. PMID 15595646.
Tsai RY, McKay RD (2005). "A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin.". J. Cell Biol. 168 (2): 179–84. doi:10.1083/jcb.200409053. PMID 15657390.
Politz JC, Polena I, Trask I, et al. (2005). "A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin.". Mol. Biol. Cell 16 (7): 3401–10. doi:10.1091/mbc.E05-02-0106. PMID 15857956.
Han C, Zhang X, Xu W, et al. (2005). "Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells.". Int. J. Mol. Med. 16 (2): 205–13. PMID 16012751.
Yang HX, Jin GL, Meng L, et al. (2005). "Screening and identification of proteins interacting with nucleostemin.". World J. Gastroenterol. 11 (31): 4812–4. PMID 16097049.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kafienah W, Mistry S, Williams C, Hollander AP (2006). "Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow.". Stem Cells 24 (4): 1113–20. doi:10.1634/stemcells.2005-0416. PMID 16282439.
Fan Y, Liu Z, Zhao S, et al. (2006). "Nucleostemin mRNA is expressed in both normal and malignant renal tissues.". Br. J. Cancer 94 (11): 1658–62. doi:10.1038/sj.bjc.6603145. PMID 16670719.
Lacina L, Smetana K, Dvoránková B, et al. (2006). "Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells?". J. Dermatol. Sci. 44 (2): 73–80. doi:10.1016/j.jdermsci.2006.08.008. PMID 17000083.
Zhu Q, Yasumoto H, Tsai RY (2007). "Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability.". Mol. Cell. Biol. 26 (24): 9279–90. doi:10.1128/MCB.00724-06. PMID 17000763.
Liu SJ, Zhang ZH, Zhang DQ, et al. (2007). "Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray.". J. Exp. Clin. Cancer Res. 25 (4): 575–83. PMID 17310849.