GNG2

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), gamma 2

PDB rendering based on 1gg2.

Available structures: 1gg2, 1gp2, 1omw, 1xhm, 2bcj

Identifiers

Symbol(s)

GNG2;

External IDs

OMIM: 606981 MGI: 102705 HomoloGene: 40715

Gene ontology
Molecular Function:	• signal transducer activity
Cellular Component:	• heterotrimeric G-protein complex • membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • cell proliferation

Orthologs

Human

Mouse

Refseq

NM_053064 (mRNA)
NP_444292 (protein)

NM_001038637 (mRNA)
NP_001033726 (protein)

Location

Chr 14: 51.38 - 51.5 Mb

Chr 14: 18.66 - 18.77 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), gamma 2, also known as GNG2, is a human gene.^[1]

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2.

[edit] Further reading

Pumiglia KM, LeVine H, Haske T, et al. (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase.". J. Biol. Chem. 270 (24): 14251-4. PMID 7782277.
Tsukada S, Simon MI, Witte ON, Katz A (1994). "Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11256-60. PMID 7972043.
Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.". J. Biol. Chem. 271 (12): 7141-6. PMID 8636150.
De Waard M, Liu H, Walker D, et al. (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels.". Nature 385 (6615): 446-50. doi:10.1038/385446a0. PMID 9009193.
Kostenis E, Conklin BR, Wess J (1997). "Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits.". Biochemistry 36 (6): 1487-95. doi:10.1021/bi962554d. PMID 9063897.
Qin N, Platano D, Olcese R, et al. (1997). "Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866-71. PMID 9238069.
Ong OC, Hu K, Rong H, et al. (1997). "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2).". Genomics 44 (1): 101-9. doi:10.1006/geno.1997.4814. PMID 9286705.
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits.". FEBS Lett. 459 (2): 186-90. PMID 10518015.
Carman CV, Barak LS, Chen C, et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.". J. Biol. Chem. 275 (14): 10443-52. PMID 10744734.
Modarressi MH, Taylor KE, Wolfe J (2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit.". Biochem. Biophys. Res. Commun. 272 (2): 610-5. doi:10.1006/bbrc.2000.2832. PMID 10833460.
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.". J. Biol. Chem. 276 (26): 23945-53. doi:10.1074/jbc.M101154200. PMID 11294873.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392-403. doi:10.1101/gr.175501. PMID 11483580.
Lowry WE, Huang XY (2002). "G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase.". J. Biol. Chem. 277 (2): 1488-92. doi:10.1074/jbc.M110390200. PMID 11698416.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.". J. Biol. Chem. 278 (9): 7220-6. doi:10.1074/jbc.M210304200. PMID 12486123.
Melliti K, Grabner M, Seabrook GR (2003). "The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells.". J. Physiol. (Lond.) 546 (Pt 2): 337-47. PMID 12527722.
Wolfe JT, Wang H, Howard J, et al. (2003). "T-type calcium channel regulation by specific G-protein betagamma subunits.". Nature 424 (6945): 209-13. doi:10.1038/nature01772. PMID 12853961.
Niu J, Profirovic J, Pan H, et al. (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.". Circ. Res. 93 (9): 848-56. doi:10.1161/01.RES.0000097607.14733.0C. PMID 14512443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Doering CJ, Kisilevsky AE, Feng ZP, et al. (2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels.". J. Biol. Chem. 279 (28): 29709-17. doi:10.1074/jbc.M308693200. PMID 15105422.