GNB1

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), beta polypeptide 1

PDB rendering based on 1a0r.

Available structures: 1a0r, 1b9x, 1b9y, 1gg2, 1got, 1gp2, 1omw, 1tbg, 1xhm, 2bcj, 2trc

Identifiers

Symbol(s)

GNB1;

External IDs

OMIM: 139380 MGI: 95781 HomoloGene: 55532

Gene ontology
Molecular Function:	• GTPase activity • signal transducer activity
Cellular Component:	• heterotrimeric G-protein complex
Biological Process:	• signal transduction • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • acetylcholine receptor signaling, muscarinic pathway • Ras protein signal transduction • cell proliferation • sensory perception of taste

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002074 (mRNA)
NP_002065 (protein)

NM_008142 (mRNA)
NP_032168 (protein)

Location

Chr 1: 1.71 - 1.81 Mb

Chr 4: 154.34 - 154.4 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), beta polypeptide 1, also known as GNB1, is a human gene.^[1]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.^[1]

[edit] References

^ ^a ^b Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1.

[edit] Further reading

Downes GB, Gautam N (2000). "The G protein subunit gene families.". Genomics 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
Levine MA, Modi WS, O'Brien SJ (1991). "Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man.". Genomics 8 (2): 380–6. PMID 1979057.
Codina J, Stengel D, Woo SL, Birnbaumer L (1986). "Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical.". FEBS Lett. 207 (2): 187–92. PMID 3095147.
Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.". J. Biol. Chem. 270 (34): 19828–32. PMID 7649993.
Ray K, Kunsch C, Bonner LM, Robishaw JD (1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.". J. Biol. Chem. 270 (37): 21765–71. PMID 7665596.
Kozasa T, Gilman AG (1995). "Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z.". J. Biol. Chem. 270 (4): 1734–41. PMID 7829508.
Tsukada S, Simon MI, Witte ON, Katz A (1994). "Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11256–60. PMID 7972043.
Ueda N, Iñiguez-Lluhi JA, Lee E, et al. (1994). "G protein beta gamma subunits. Simplified purification and properties of novel isoforms.". J. Biol. Chem. 269 (6): 4388–95. PMID 8308009.
Wall MA, Coleman DE, Lee E, et al. (1996). "The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.". Cell 83 (6): 1047–58. PMID 8521505.
Sondek J, Bohm A, Lambright DG, et al. (1996). "Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.". Nature 379 (6563): 369–74. doi:10.1038/379369a0. PMID 8552196.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Mattingly RR, Macara IG (1996). "Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.". Nature 382 (6588): 268–72. doi:10.1038/382268a0. PMID 8717044.
De Waard M, Liu H, Walker D, et al. (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels.". Nature 385 (6615): 446–50. doi:10.1038/385446a0. PMID 9009193.
Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.". FEBS Lett. 405 (3): 291–8. PMID 9108307.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Qin N, Platano D, Olcese R, et al. (1997). "Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866–71. PMID 9238069.
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits.". FEBS Lett. 459 (2): 186–90. PMID 10518015.
Huang L, Shanker YG, Dubauskaite J, et al. (2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481.
Carman CV, Barak LS, Chen C, et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.". J. Biol. Chem. 275 (14): 10443–52. PMID 10744734.