GNAI2

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Identifiers

GNAI2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1

External IDs

OMIM: 139360 MGI: 95772 HomoloGene: 55539

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • signal transducer activity • protein binding • GTP binding • guanyl nucleotide binding
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase inhibiting pathway • negative regulation of adenylate cyclase activity • acetylcholine receptor signaling, muscarinic pathway • response to nutrient • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002070 (mRNA)
NP_002061 (protein)

XM_980919 (mRNA)
XP_986013 (protein)

Location

Chr 3: 50.24 - 50.27 Mb

n/a

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, also known as GNAI2, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.

[edit] Further reading

Sidhu A, Niznik HB (2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins.". Int. J. Dev. Neurosci. 18 (7): 669–77. PMID 10978845.
Offermanns S, Schultz G, Rosenthal W (1991). "Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells.". J. Biol. Chem. 266 (6): 3365–8. PMID 1671672.
Cormont M, Le Marchand-Brustel Y, Van Obberghen E, et al. (1991). "Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.". Diabetes 40 (9): 1170–6. PMID 1718802.
Magovcevic I, Ang SL, Seidman JG, et al. (1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13.". Genomics 12 (1): 125–9. PMID 1733849.
Bushfield M, Murphy GJ, Lavan BE, et al. (1990). "Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.". Biochem. J. 268 (2): 449–57. PMID 2114093.
Lyons J, Landis CA, Harsh G, et al. (1990). "Two G protein oncogenes in human endocrine tumors.". Science 249 (4969): 655–9. PMID 2116665.
Osawa S, Dhanasekaran N, Woon CW, Johnson GL (1990). "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.". Cell 63 (4): 697–706. PMID 2121366.
McClue SJ, Milligan G (1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.". FEBS Lett. 269 (2): 430–4. PMID 2169434.
Rudolph U, Koesling D, Hinsch KD, et al. (1989). "G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.". Mol. Cell. Endocrinol. 63 (1-2): 143–53. PMID 2502457.
Lang JC, Costa T (1990). "Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o.". J. Recept. Res. 9 (4-5): 313–29. PMID 2512386.
Itoh H, Toyama R, Kozasa T, et al. (1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.". J. Biol. Chem. 263 (14): 6656–64. PMID 2834384.
Weinstein LS, Spiegel AM, Carter AD (1988). "Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein.". FEBS Lett. 232 (2): 333–40. PMID 2837412.
Didsbury JR, Ho YS, Snyderman R (1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA.". FEBS Lett. 211 (2): 160–4. PMID 3100330.
Beals CR, Wilson CB, Perlmutter RM (1987). "A small multigene family encodes Gi signal-transduction proteins.". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7886–90. PMID 3120178.
Williamson EA, Ince PG, Harrison D, et al. (1995). "G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas.". Eur. J. Clin. Invest. 25 (2): 128–31. PMID 7737262.
Takigawa M, Sakurai T, Kasuya Y, et al. (1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors.". Eur. J. Biochem. 228 (1): 102–8. PMID 7882989.
Grassie MA, Milligan G (1995). "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.". Biochem. J. 306 ( Pt 2): 525–30. PMID 7887906.
Migeon JC, Thomas SL, Nathanson NM (1994). "Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha.". J. Biol. Chem. 269 (46): 29146–52. PMID 7961880.
Wennogle LP, Conder L, Winter C, et al. (1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding.". J. Cell. Biochem. 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171.
Valet P, Senard JM, Devedjian JC, et al. (1993). "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.". J. Clin. Invest. 91 (5): 2049–57. PMID 8098045.

This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

v • d • e Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)

3.6.5.1: Heterotrimeric G protein	G_αs - G_αi (GNAI1, GNAI2, GNAI3) - G_αq/11 (GNAQ, GNA11) - G_α12/13 (GNA12, GNA13) - Transducin (GNAT1, GNAT2)

3.6.5.2: Small GTPase > Ras superfamily	Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap

3.6.5.3: Elongation factor	Prokaryotic - Eukaryotic

3.6.5.5-6: Other	Dynamin (is a GTPase, is not a G protein) - Tubulin