GMEB2

From Wikipedia, the free encyclopedia

Glucocorticoid modulatory element binding protein 2

Identifiers

GMEB2; KIAA1269; P79PIF; PIF79

External IDs

OMIM: 607451 MGI: 2652836 HomoloGene: 8228

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012384 (mRNA)
NP_036516 (protein)

NM_198169 (mRNA)
NP_937812 (protein)

Location

Chr 20: 61.69 - 61.73 Mb

Chr 2: 181.18 - 181.22 Mb

Pubmed search

[1]

[2]

Glucocorticoid modulatory element binding protein 2, also known as GMEB2, is a human gene.^[1]

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.^[1]

[edit] References

^ ^a ^b Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2.

[edit] Further reading

Christensen J, Cotmore SF, Tattersall P (1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites.". Mol. Cell. Biol. 19 (11): 7741–50. PMID 10523663.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Kaul S, Blackford JA, Chen J, et al. (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.". Mol. Endocrinol. 14 (7): 1010–27. PMID 10894151.
Burnett E, Christensen J, Tattersall P (2002). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters.". J. Mol. Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID 11743720.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors.". J. Biol. Chem. 277 (15): 12541–9. doi:10.1074/jbc.M112330200. PMID 11812797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.