Talk:Glyceraldehyde 3-phosphate dehydrogenase

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Contents

[edit] prokaryote and eukaryote?

is GADPH used by both eukaryotes and prokaryotes?

Probably it is, because gycolysis is performed by both euk. and prok. --Christopherlin 15:22, 21 March 2006 (UTC)

[edit] Additional source

This page http://www.biochem.ucl.ac.uk/bsm/enzymes/ec1/ec02/ec01/ec0012/ explains the EC classification of the enzyme. --Christopherlin 15:22, 21 March 2006 (UTC)

[edit] water

"Finally, a molecule of inorganic phosphate attacks the thioester and forms a tetrahedral intermediate, which then collapses to release 1,3-bisphosphoglycerate, a molecule of water, and the thiol group of the enzyme's cysteine residue." - where does the water come from?

  • This was a mistake and has since been corrected. Jasu 13:45, 23 August 2007 (UTC)

[edit] Molecular Weight

What's its molecular weight and what is its quaternary structure (monomer, dimer, tetramer... ?)

[edit] writing level

is it just me or is this article waaayyyy too technical for an encyclopedia entry? i feel like it should be written more layman-ish and provide references for the extra details. —The preceding unsigned comment was added by 141.213.67.125 (talk) 18:24, 22 February 2007 (UTC).

  • You are right but should more complex information be included for the article to be easy to read? I think the best way forward is to write a widely understood lead section for the article (which I attempted just know) and give more complex information deeper down in the article. In this way, a general reader can understand the topic by reading the leader and specialists may find the article interesting as well. Jasu 13:21, 23 August 2007 (UTC)

[edit] extreme makeover

I spend 2-3 hours reworking this article. This included:

  • extended lead section in plain English
  • more subdivision of the article with headings to facilitate targeted reading
  • new sections on recently discovered functions of GAPDH in transcription, apoptosis, and vesicle formation
  • plus reference section

After this significant extension, I removed the stub markers. Thanks to glycolysis for providing me with energy to write this.

Jasu 13:25, 23 August 2007 (UTC)