Glycosphingolipid deacylase

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In enzymology, a glycosphingolipid deacylase (EC 3.5.1.69) is an enzyme that catalyzes a chemical reaction that cleaves gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is glycosphingolipid amidohydrolase. This enzyme is also called glycosphingolipid ceramide deacylase.

[edit] References

• IUBMB entry for 3.5.1.69
• BRENDA references for 3.5.1.69 (Recommended.)
• PubMed references for 3.5.1.69
• PubMed Central references for 3.5.1.69
• Google Scholar references for 3.5.1.69
• Tochikura T (Tokyo). "A novel glycosphingolipid hydrolyzing enzyme, glycosphingolipid ceramide deacylase, which cleaves the linkage between the fatty acid and sphingosine base in glycosphingolipids". J. Biochem.: 1–4. PMID 3360750. 

[edit] External links

The CAS registry number for this enzyme class is 122544-53-0.

• IUBMB entry for 3.5.1.69

• KEGG entry for 3.5.1.69

• BRENDA entry for 3.5.1.69

• NiceZyme view of 3.5.1.69

• EC2PDB: PDB structures for 3.5.1.69

• PRIAM entry for 3.5.1.69

• PUMA2 entry for 3.5.1.69

• IntEnz: Integrated Enzyme entry for 3.5.1.69

• MetaCyc entry for 3.5.1.69

• Atomic-resolution structures of enzymes belonging to this class