Glycerophospholipid acyltransferase (CoA-dependent)

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In enzymology, a glycerophospholipid acyltransferase (CoA-dependent) (EC 2.3.1.148) is an enzyme that catalyzes the chemical reaction

1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine $\rightleftharpoons$ 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are 1-organyl-2-acyl-sn-glycero-3-phosphocholine and 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine, whereas its two products are 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine and 1-organyl-2-lyso-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-gly cero-3-phosphoethanolamine acyltransferase (CoA-dependent).

[edit] References

IUBMB entry for 2.3.1.148
BRENDA references for 2.3.1.148 (Recommended.)
PubMed references for 2.3.1.148
PubMed Central references for 2.3.1.148
Google Scholar references for 2.3.1.148
Irvine RF, Dawson RM (1979). "Transfer of arachidonic acid between phospholipids in rat liver microsomes". Biochem. Biophys. Res. Commun. 91: 1399–405. doi:10.1016/0006-291X(79)91222-1. PMID 526311.
Robinson M, Blank ML, Snyder F (1985). "Acylation of lysophospholipids by rabbit alveolar macrophages Specificities of CoA-dependent and CoA-independent reactions". J. Biol. Chem. 260: 7889–95. PMID 4008481.
Snyder F, Lee TC, Blank ML (1992). "The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid. Res. 31: 65–86. doi:10.1016/0163-7827(92)90016-C. PMID 1641397.