Glutathione S-transferase Mu 1

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Glutathione S-transferase M1
PDB rendering based on 1gtu.
Available structures: 1gtu, 1xw6, 1xwk, 1yj6, 2f3m
Identifiers
Symbol(s)	GSTM1; GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MGC26563; MU; MU-1
External IDs	OMIM: 138350 MGI: 95861 HomoloGene: 84561
Gene ontology Molecular Function: • glutathione transferase activity • transferase activity Cellular Component: • cytoplasm Biological Process: • metabolic process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2944	14863
Ensembl	ENSG00000134184	n/a
Uniprot	P09488	n/a
Refseq	NM_000561 (mRNA) NP_000552 (protein)	NM_008183 (mRNA) NP_032209 (protein)
Location	Chr 1: 110.03 - 110.04 Mb	n/a
Pubmed search	[1]	[2]

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.^[1]

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