Glutamin-(asparagin-)ase

From Wikipedia, the free encyclopedia

In enzymology, a glutamin-(asparagin-)ase (EC 3.5.1.38) is an enzyme that catalyzes the chemical reaction

L-glutamine + H₂O L-glutamate + NH₃

Thus, the two substrates of this enzyme are L-glutamine and H₂O, whereas its two products are L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-glutamine(L-asparagine) amidohydrolase. This enzyme participates in 4 metabolic pathways: glutamate metabolism, alanine and aspartate metabolism, d-glutamine and d-glutamate metabolism, and nitrogen metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DJO, 1DJP, and 4PGA.

[edit] References

• IUBMB entry for 3.5.1.38
• BRENDA references for 3.5.1.38 (Recommended.)
• PubMed references for 3.5.1.38
• PubMed Central references for 3.5.1.38
• Google Scholar references for 3.5.1.38
• Roberts J, Holcenberg JS, Dolowy WC (1972). "Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity". J. Biol. Chem. 247: 84–90. PMID 5017769. 

[edit] External links

The CAS registry number for this enzyme class is 39335-03-0.

• IUBMB entry for 3.5.1.38

• KEGG entry for 3.5.1.38

• BRENDA entry for 3.5.1.38

• NiceZyme view of 3.5.1.38

• EC2PDB: PDB structures for 3.5.1.38

• PRIAM entry for 3.5.1.38

• PUMA2 entry for 3.5.1.38

• IntEnz: Integrated Enzyme entry for 3.5.1.38

• MetaCyc entry for 3.5.1.38

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050417: glutamin-(asparagin-)ase

• AMIGO entry for GO code 0050417: glutamin-(asparagin-)ase