Glutamate 5-kinase

From Wikipedia, the free encyclopedia

In enzymology, a glutamate 5-kinase (EC 2.7.2.11) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate ADP + L-glutamate 5-phosphate

Thus, the two substrates of this enzyme are ATP and L-glutamate, whereas its two products are ADP and L-glutamate 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:L-glutamate 5-phosphotransferase. Other names in common use include ATP-L-glutamate 5-phosphotransferase, ATP:gamma-L-glutamate phosphotransferase, gamma-glutamate kinase, gamma-glutamyl kinase, and glutamate kinase. This enzyme participates in urea cycle and metabolism of amino groups.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2AKO, 2J5T, and 2J5V.

[edit] References

• IUBMB entry for 2.7.2.11
• BRENDA references for 2.7.2.11 (Recommended.)
• PubMed references for 2.7.2.11
• PubMed Central references for 2.7.2.11
• Google Scholar references for 2.7.2.11
• Baich A (1969). "Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase". Biochim. Biophys. Acta. 192: 462–7. PMID 4904678. 

[edit] External links

The CAS registry number for this enzyme class is 54596-30-4.

• IUBMB entry for 2.7.2.11

• KEGG entry for 2.7.2.11

• BRENDA entry for 2.7.2.11

• NiceZyme view of 2.7.2.11

• EC2PDB: PDB structures for 2.7.2.11

• PRIAM entry for 2.7.2.11

• PUMA2 entry for 2.7.2.11

• IntEnz: Integrated Enzyme entry for 2.7.2.11

• MetaCyc entry for 2.7.2.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004349: glutamate 5-kinase

• AMIGO entry for GO code 0004349: glutamate 5-kinase