Glucosamine-phosphate N-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a glucosamine-phosphate N-acetyltransferase (EC 2.3.1.4) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + D-glucosamine 6-phosphate $\rightleftharpoons$ CoA + N-acetyl-D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are acetyl-CoA and D-glucosamine 6-phosphate, whereas its two products are CoA and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase. Other names in common use include phosphoglucosamine transacetylase, phosphoglucosamine acetylase, glucosamine-6-phosphate acetylase, D-glucosamine-6-P N-acetyltransferase, aminodeoxyglucosephosphate acetyltransferase, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, N-acetylglucosamine-6-phosphate synthase, phosphoglucosamine N-acetylase, glucosamine-phosphate N-acetyltransferase, and glucosamine-6-phosphate N-acetyltransferase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1I12, 1I1D, 1I21, 2HUZ, and 2O28.

[edit] References

IUBMB entry for 2.3.1.4
BRENDA references for 2.3.1.4 (Recommended.)
PubMed references for 2.3.1.4
PubMed Central references for 2.3.1.4
Google Scholar references for 2.3.1.4
Davidson EA (1966). "Glucosamine 6-phosphate N-acetylase". Methods Enzymol. 9: 704–707.
DAVIDSON EA, BLUMENTHAL HJ, ROSEMAN S (1957). "Glucosamine metabolism. II. Studies on glucosamine 6-phosphate N-acetylase". J. Biol. Chem. 226: 125–33. PMID 13428743.
PATTABIRAMAN TN, BACHHAWAT BK (1962). "Purification of glucosamine-6-phosphate N-acetylase from sheep brain". Biochim. Biophys. Acta. 59: 681–9. PMID 14484387.
Hui CC, Chung S, Huber LA, Mak TW, Iscove NN (2000). "Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association". J. Biol. Chem. 275: 12821–32. PMID 10777580.