Glucarate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a glucarate dehydratase (EC 4.2.1.40) is an enzyme that catalyzes the chemical reaction

D-glucarate 5-dehydro-4-deoxy-D-glucarate + H₂O

Hence, this enzyme has one substrate, D-glucarate, and two products, 5-dehydro-4-deoxy-D-glucarate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming). Other names in common use include D-glucarate dehydratase, and D-glucarate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BQG, 1EC7, 1EC8, 1EC9, 1ECQ, 1JCT, and 1JDF.

[edit] References

• IUBMB entry for 4.2.1.40
• BRENDA references for 4.2.1.40 (Recommended.)
• PubMed references for 4.2.1.40
• PubMed Central references for 4.2.1.40
• Google Scholar references for 4.2.1.40
• Blumenthal HJ (1966). "D-Glucarate dehydrase". Methods Enzymol. 9: 660–665. 

[edit] External links

The CAS registry number for this enzyme class is 9059-02-3.

• IUBMB entry for 4.2.1.40

• KEGG entry for 4.2.1.40

• BRENDA entry for 4.2.1.40

• NiceZyme view of 4.2.1.40

• EC2PDB: PDB structures for 4.2.1.40

• PRIAM entry for 4.2.1.40

• PUMA2 entry for 4.2.1.40

• IntEnz: Integrated Enzyme entry for 4.2.1.40

• MetaCyc entry for 4.2.1.40

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008872: glucarate dehydratase

• AMIGO entry for GO code 0008872: glucarate dehydratase