GLIPR1

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GLI pathogenesis-related 1 (glioma)
Identifiers
Symbol(s) GLIPR1; CRISP7; GLIPR; RTVP1
External IDs OMIM: 602692 MGI: 1920940 HomoloGene: 21357
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11010 73690
Ensembl ENSG00000139278 ENSMUSG00000056888
Uniprot P48060 Q4QQK5
Refseq NM_006851 (mRNA)
NP_006842 (protein)		 NM_028608 (mRNA)
NP_082884 (protein)
Location Chr 12: 74.16 - 74.18 Mb Chr 10: 111.39 - 111.4 Mb
Pubmed search [1] [2]

GLI pathogenesis-related 1 (glioma), also known as GLIPR1, is a human gene.[1]

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: GLIPR1 GLI pathogenesis-related 1 (glioma).

[edit] Further reading

  • Murphy EV, Zhang Y, Zhu W, Biggs J (1995). "The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.". Gene 159 (1): 131-5. PMID 7607567. 
  • Rich T, Chen P, Furman F, et al. (1997). "RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin.". Gene 180 (1-2): 125-30. PMID 8973356. 
  • Szyperski T, Fernández C, Mumenthaler C, Wüthrich K (1998). "Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2262-6. PMID 9482873. 
  • Gingras MC, Margolin JF (2000). "Differential expression of multiple unexpected genes during U937 cell and macrophage differentiation detected by suppressive subtractive hybridization.". Exp. Hematol. 28 (3): 350. PMID 10720702. 
  • Ren C, Li L, Goltsov AA, et al. (2002). "mRTVP-1, a novel p53 target gene with proapoptotic activities.". Mol. Cell. Biol. 22 (10): 3345-57. PMID 11971968. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Ren C, Li L, Yang G, et al. (2004). "RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.". Cancer Res. 64 (3): 969-76. PMID 14871827. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ren C, Ren CH, Li L, et al. (2006). "Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.". Genomics 88 (2): 163-72. doi:10.1016/j.ygeno.2006.03.021. PMID 16714093. 
  • Xiang C, Sarid R, Cazacu S, et al. (2007). "Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.". Biochem. Biophys. Res. Commun. 362 (3): 612-8. doi:10.1016/j.bbrc.2007.08.138. PMID 17825796. 
  • Chilukamarri L, Hancock AL, Malik S, et al. (2007). "Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors.". Neoplasia 9 (11): 970-8. PMID 18030365. 
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