GLE1L

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GLE1 RNA export mediator-like (yeast)
Identifiers
Symbol(s) GLE1L; hGLE1
External IDs OMIM: 603371 MGI: 1921662 HomoloGene: 20379
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2733 74412
Ensembl ENSG00000119392 ENSMUSG00000019715
Uniprot Q53GS7 Q8R322
Refseq NM_001003722 (mRNA)
NP_001003722 (protein)		 NM_028923 (mRNA)
NP_083199 (protein)
Location Chr 9: 130.31 - 130.34 Mb Chr 2: 29.76 - 29.78 Mb
Pubmed search [1] [2]

GLE1 RNA export mediator-like (yeast), also known as GLE1L, is a human gene.[1]

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: GLE1L GLE1 RNA export mediator-like (yeast).

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Watkins JL, Murphy R, Emtage JL, Wente SR (1998). "The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6779–84. PMID 9618489. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kendirgi F, Barry DM, Griffis ER, et al. (2003). "An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.". J. Cell Biol. 160 (7): 1029–40. doi:10.1083/jcb.200211081. PMID 12668658. 
  • Rayala HJ, Kendirgi F, Barry DM, et al. (2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.". Mol. Cell Proteomics 3 (2): 145–55. doi:10.1074/mcp.M300106-MCP200. PMID 14645504. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kendirgi F, Rexer DJ, Alcázar-Román AR, et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.". Mol. Biol. Cell 16 (9): 4304–15. doi:10.1091/mbc.E04-11-0998. PMID 16000379. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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