GIT1

From Wikipedia, the free encyclopedia

G protein-coupled receptor kinase interactor 1

Identifiers

External IDs

OMIM: 608434 MGI: 1927140 HomoloGene: 32204

Gene ontology
Molecular Function:	• receptor activity • GTPase activator activity • protein binding • zinc ion binding • kinase activity • metal ion binding
Biological Process:	• regulation of G-protein coupled receptor protein signaling pathway • regulation of GTPase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014030 (mRNA)
NP_054749 (protein)

NM_001004144 (mRNA)
NP_001004144 (protein)

Location

Chr 17: 24.92 - 24.94 Mb

Chr 11: 77.31 - 77.32 Mb

Pubmed search

[1]

[2]

G protein-coupled receptor kinase interactor 1, also known as GIT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GIT1 G protein-coupled receptor kinase interactor 1.

[edit] Further reading

Hoefen RJ, Berk BC (2006). "The multifunctional GIT family of proteins.". J. Cell. Sci. 119 (Pt 8): 1469–75. doi:10.1242/jcs.02925. PMID 16598076.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Premont RT, Claing A, Vitale N, et al. (1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082–7. PMID 9826657.
Premont RT, Claing A, Vitale N, et al. (2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.". J. Biol. Chem. 275 (29): 22373–80. PMID 10896954.
Zhao ZS, Manser E, Loo TH, Lim L (2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.". Mol. Cell. Biol. 20 (17): 6354–63. PMID 10938112.
Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system.". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–8. doi:10.1073/pnas.041608698. PMID 11381105.
Manabe R, Kovalenko M, Webb DJ, Horwitz AR (2002). "GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.". J. Cell. Sci. 115 (Pt 7): 1497–510. PMID 11896197.
Nishiya N, Shirai T, Suzuki W, Nose K (2003). "Hic-5 interacts with GIT1 with a different binding mode from paxillin.". J. Biochem. 132 (2): 279–89. PMID 12153727.
Kim S, Ko J, Shin H, et al. (2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.". J. Biol. Chem. 278 (8): 6291–300. doi:10.1074/jbc.M212287200. PMID 12473661.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shin H, Wyszynski M, Huh KH, et al. (2003). "Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha.". J. Biol. Chem. 278 (13): 11393–401. doi:10.1074/jbc.M211874200. PMID 12522103.
Ko J, Kim S, Valtschanoff JG, et al. (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003). "Synapse formation is regulated by the signaling adaptor GIT1.". J. Cell Biol. 161 (1): 131–42. doi:10.1083/jcb.200211002. PMID 12695502.
Ko J, Na M, Kim S, et al. (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Haendeler J, Yin G, Hojo Y, et al. (2004). "GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor.". J. Biol. Chem. 278 (50): 49936–44. doi:10.1074/jbc.M307317200. PMID 14523024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
van Nieuw Amerongen GP, Natarajan K, Yin G, et al. (2004). "GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.". Circ. Res. 94 (8): 1041–9. doi:10.1161/01.RES.0000125627.77235.0C. PMID 15016733.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.