GFRA3

From Wikipedia, the free encyclopedia

GDNF family receptor alpha 3

PDB rendering based on 2gh0.

Available structures: 2gh0

Identifiers

Symbol(s)

GFRA3;

External IDs

OMIM: 605710 MGI: 1201403 HomoloGene: 1146

Gene ontology
Molecular Function:	• receptor activity • receptor binding • axon guidance receptor activity • GPI anchor binding
Cellular Component:	• external side of plasma membrane • membrane • extrinsic to membrane
Biological Process:	• signal transduction • axon guidance • peripheral nervous system development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001496 (mRNA)
NP_001487 (protein)

XM_989428 (mRNA)
XP_994522 (protein)

Location

Chr 5: 137.62 - 137.64 Mb

Chr 18: 34.81 - 34.85 Mb

Pubmed search

[1]

[2]

GDNF family receptor alpha 3, also known as GFRA3, is a human gene.^[1]

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.^[1]

[edit] References

^ ^a ^b Entrez Gene: GFRA3 GDNF family receptor alpha 3.

[edit] Further reading

Wang X, Baloh RH, Milbrandt J, Garcia KC (2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.". Structure 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gimm O, Dziema H, Brown J, et al. (2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma.". Oncogene 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
Onochie CI, Korngut LM, Vanhorne JB, et al. (2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease.". J. Med. Genet. 37 (9): 674–9. PMID 10978357.
Baloh RH, Tansey MG, Lampe PA, et al. (1999). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.". Neuron 21 (6): 1291–302. PMID 9883723.
Baloh RH, Gorodinsky A, Golden JP, et al. (1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5801–6. PMID 9576965.
Masure S, Cik M, Pangalos MN, et al. (1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3).". Eur. J. Biochem. 251 (3): 622–30. PMID 9490034.
Jing S, Yu Y, Fang M, et al. (1998). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.". J. Biol. Chem. 272 (52): 33111–7. PMID 9407096.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.