Gentamicin 2'-N-acetyltransferase

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In enzymology, a gentamicin 2'-N-acetyltransferase (EC 2.3.1.59) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + gentamicin C₁a CoA + N₂'-acetylgentamicin C₁a

Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C1a, whereas its two products are CoA and N2'-acetyl gentamicin C1a.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C1a N2'-acetyltransferase. Other names in common use include gentamicin acetyltransferase II, gentamicin 2'-N-acetyltransferase, and acetyl-CoA:gentamicin-C1a N2'-acetyltransferase.

[edit] References

• IUBMB entry for 2.3.1.59
• BRENDA references for 2.3.1.59 (Recommended.)
• PubMed references for 2.3.1.59
• PubMed Central references for 2.3.1.59
• Google Scholar references for 2.3.1.59
• Benveniste R, Davies J (1973). "Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria". Proc. Natl. Acad. Sci. U. S. A. 70: 2276–80. PMID 4209515. 

[edit] External links

The CAS registry number for this enzyme class is 50864-40-9.

• IUBMB entry for 2.3.1.59

• KEGG entry for 2.3.1.59

• BRENDA entry for 2.3.1.59

• NiceZyme view of 2.3.1.59

• EC2PDB: PDB structures for 2.3.1.59

• PRIAM entry for 2.3.1.59

• PUMA2 entry for 2.3.1.59

• IntEnz: Integrated Enzyme entry for 2.3.1.59

• MetaCyc entry for 2.3.1.59

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047921: gentamicin 2'-N-acetyltransferase

• AMIGO entry for GO code 0047921: gentamicin 2'-N-acetyltransferase