Genotoxicity

From Wikipedia, the free encyclopedia

Look up Genotoxicity in
Wiktionary, the free dictionary.

Genotoxicity describes a deleterious action on a cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogen, specifically those capable of causing genetic mutation and of contributing to the development of tumors. This includes both certain chemical compounds and certain types of radiation.

Typical genotoxins like aromatic amines are believed to cause mutations because they are electrophilic and form strong covalent bonds with DNA resulting with the formation of Aromatic Amine-DNA Adducts, preventing accurate replication.

[edit] See also

Mutagen

[edit] References

 This biology article is a stub. You can help Wikipedia by expanding it.
Languages