GEFT

From Wikipedia, the free encyclopedia

RAC/CDC42 exchange factor

Identifiers

GEFT; p63RhoGEF

External IDs

OMIM: 610215 MGI: 1277173 HomoloGene: 32691

Gene ontology
Molecular Function:	• Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of Rho protein signal transduction

Orthologs

Human

Mouse

n/a

Refseq

NM_133483 (mRNA)
NP_597840 (protein)

NM_028027 (mRNA)
NP_082303 (protein)

Location

n/a

Chr 10: 126.59 - 126.59 Mb

Pubmed search

[1]

[2]

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[1]

[edit] References

^ Entrez Gene: GEFT RAC/CDC42 exchange factor.

[edit] Further reading

Lutz S, Shankaranarayanan A, Coco C, et al. (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.". Science 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806.
Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360.
Bryan BA, Mitchell DC, Zhao L, et al. (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMID 16314529.
Lutz S, Freichel-Blomquist A, Yang Y, et al. (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
Bryan B, Kumar V, Stafford LJ, et al. (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
Lutz S, Freichel-Blomquist A, Rümenapp U, et al. (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594.
Guo X, Stafford LJ, Bryan B, et al. (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Souchet M, Portales-Casamar E, Mazurais D, et al. (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.". J. Cell. Sci. 115 (Pt 3): 629–40. PMID 11861769.