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| Gammaretrovirus core encapsidation signal |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
101.0 nucleotides |
| Avg identity: |
93% |
|
The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.
[edit] References
- ^ D'Souza, V; Dey A, Habib D, Summers MF (2004). "NMR structure of the 101-nucleotide core encapsidation signal of the Moloney Murine Leukemia Virus". J Mol Biol 337: 427–442. doi:10.1016/j.jmb.2004.01.037. PMID 15003457.
- ^ D'Souza, V; Summers MF (2004). "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus". Nature. 431: 586–590. doi:10.1038/nature02944. PMID 15457265.
[edit] External links
