Gamma-glutamylcyclotransferase

From Wikipedia, the free encyclopedia

In enzymology, a gamma-glutamylcyclotransferase (EC 2.3.2.4) is an enzyme that catalyzes the chemical reaction

(5-L-glutamyl)-L-amino acid $\rightleftharpoons$ 5-oxoproline + L-amino acid

Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2PN7 and 2RBH.

[edit] References

IUBMB entry for 2.3.2.4
BRENDA references for 2.3.2.4 (Recommended.)
PubMed references for 2.3.2.4
PubMed Central references for 2.3.2.4
Google Scholar references for 2.3.2.4
Bodnaryk RP and McGirr L (1973). "Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L". Biochim. Biophys. Acta 315: 352–362.
Orlowski M, Richman PG and Meister A (1969). "Isolation and properties of gamma-L-glutamylcyclotransferase from human brain". Biochemistry 8: 1048–1055.