Galactosylgalactosylglucosylceramidase

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In enzymology, a galactosylgalactosylglucosylceramidase (EC 3.2.1.47) is an enzyme that catalyzes the chemical reaction

D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H₂O D-galactose + lactosyl-N-acylsphingosine

Thus, the two substrates of this enzyme are D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine and H₂O, whereas its two products are D-galactose and lactosyl-N-acylsphingosine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase. Other names in common use include trihexosyl ceramide galactosidase, ceramide trihexosidase, ceramidetrihexoside alpha-galactosidase, trihexosylceramide alpha-galactosidase, and ceramidetrihexosidase.

[edit] References

• IUBMB entry for 3.2.1.47
• BRENDA references for 3.2.1.47 (Recommended.)
• PubMed references for 3.2.1.47
• PubMed Central references for 3.2.1.47
• Google Scholar references for 3.2.1.47
• Brady RO, Gal AE, Bradley RM, Martensson E (1967). "The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide". J. Biol. Chem. 242: 1021–6. PMID 6020428. 

[edit] External links

The CAS registry number for this enzyme class is 9023-01-2.

• IUBMB entry for 3.2.1.47

• KEGG entry for 3.2.1.47

• BRENDA entry for 3.2.1.47

• NiceZyme view of 3.2.1.47

• EC2PDB: PDB structures for 3.2.1.47

• PRIAM entry for 3.2.1.47

• PUMA2 entry for 3.2.1.47

• IntEnz: Integrated Enzyme entry for 3.2.1.47

• MetaCyc entry for 3.2.1.47

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0017041: galactosylgalactosylglucosylceramidase

• AMIGO entry for GO code 0017041: galactosylgalactosylglucosylceramidase