Galactosyldiacylglycerol alpha-2,3-sialyltransferase

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In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase (EC 2.4.99.5) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol $\rightleftharpoons$ CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol, whereas its 3 products are CMP, [[1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-]], and glycerol.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase. This enzyme participates in glycerolipid metabolism.

[edit] References

IUBMB entry for 2.4.99.5
BRENDA references for 2.4.99.5 (Recommended.)
PubMed references for 2.4.99.5
PubMed Central references for 2.4.99.5
Google Scholar references for 2.4.99.5
Pieringer J, Keech S, Pieringer RA (1981). "Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes". J. Biol. Chem. 256: 12306–9. PMID 7298658.
Weinstein J, de Souza-e-Silva U, Paulson JC (1982). "Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver". J. Biol. Chem. 257: 13835–44. PMID 7142179.
Weinstein J, de Souza-e-Silva U, Paulson JC (1982). "Sialylation of glycoprotein oligosaccharides N-linked to asparagine Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver". J. Biol. Chem. 257: 13845–53. PMID 7142180.