Galactosylceramide sulfotransferase

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In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a galactosylceramide $\rightleftharpoons$ adenosine 3',5'-bisphosphate + a galactosylceramidesulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and galactosylceramide, whereas its two products are adenosine 3',5'-bisphosphate and galactosylceramidesulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase. Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside sulfotransferase, galactolipid sulfotransferase, glycolipid sulfotransferase, and glycosphingolipid sulfotransferase. This enzyme participates in sphingolipid metabolism.

[edit] References

IUBMB entry for 2.8.2.11
BRENDA references for 2.8.2.11 (Recommended.)
PubMed references for 2.8.2.11
PubMed Central references for 2.8.2.11
Google Scholar references for 2.8.2.11
McKhann GM, Levy R, Ho W (1965). "Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides". Biochem. Biophys. Res. Commun. 20: 109–13. PMID 5850675.
Sakakibara N, Gasa S, Kamio K, Makita A, Koyanagi T (1989). "Association of elevated sulfatides and sulfotransferase activities with human renal cell carcinoma". Cancer. Res. 49: 335–9. PMID 2562926.