GALNT13

From Wikipedia, the free encyclopedia

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)

Identifiers

GALNT13; FLJ16031; FLJ41157; GalNAc-T13; KIAA1918; MGC119459; MGC119461

External IDs

OMIM: 608369 MGI: 2139447 HomoloGene: 62167

Gene ontology
Molecular Function:	• polypeptide N-acetylgalactosaminyltransferase activity • calcium ion binding • sugar binding • transferase activity, transferring glycosyl groups • manganese ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid O-linked glycosylation

Orthologs

Human

Mouse

Refseq

NM_052917 (mRNA)
NP_443149 (protein)

NM_173030 (mRNA)
NP_766618 (protein)

Location

Chr 2: 154.44 - 155.02 Mb

Chr 2: 54.33 - 54.93 Mb

Pubmed search

[1]

[2]

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13), also known as GALNT13, is a human gene.^[1]

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13).

[edit] Further reading

"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179-87. PMID 11572484.
Zhang Y, Iwasaki H, Wang H, et al. (2003). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.". J. Biol. Chem. 278 (1): 573-84. doi:10.1074/jbc.M203094200. PMID 12407114.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.