G3BP2

From Wikipedia, the free encyclopedia

GTPase activating protein (SH3 domain) binding protein 2

Identifiers

External IDs

MGI: 2442040 HomoloGene: 40792

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • receptor signaling complex scaffold activity
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• transport • cytoplasmic sequestering of NF-kappaB • Ras protein signal transduction • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012297 (mRNA)
NP_036429 (protein)

NM_001080794 (mRNA)
NP_001074263 (protein)

Location

Chr 4: 76.79 - 76.82 Mb

Chr 5: 93.13 - 93.16 Mb

Pubmed search

[1]

[2]

GTPase activating protein (SH3 domain) binding protein 2, also known as G3BP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Kim MM, Wiederschain D, Kennedy D, et al. (2007). "Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).". Oncogene 26 (29): 4209–15. doi:10.1038/sj.onc.1210212. PMID 17297477.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.". Nat. Methods 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Prigent M, Barlat I, Langen H, Dargemont C (2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2.". J. Biol. Chem. 275 (46): 36441–9. doi:10.1074/jbc.M004751200. PMID 10969074.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Kennedy D, Wood SA, Ramsdale T, et al. (1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif.". Biomed. Pept. Proteins Nucleic Acids 2 (3): 93–9. PMID 9575347.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.