G3BP1

From Wikipedia, the free encyclopedia

GTPase activating protein (SH3 domain) binding protein 1

Identifiers

G3BP1; G3BP; HDH-VIII; MGC111040

External IDs

OMIM: 608431 MGI: 1351465 HomoloGene: 38096

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • DNA binding • RNA binding • ATP-dependent DNA helicase activity • ATP-dependent RNA helicase activity • helicase activity • endonuclease activity • protein binding • ATP binding • hydrolase activity
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• transport • Ras protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005754 (mRNA)
NP_005745 (protein)

XM_985138 (mRNA)
XP_990232 (protein)

Location

Chr 5: 151.13 - 151.17 Mb

Chr 11: 55.31 - 55.34 Mb

Pubmed search

[1]

[2]

GTPase activating protein (SH3 domain) binding protein 1, also known as G3BP1, is a human gene.^[1]

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1.

[edit] Further reading

Irvine K, Stirling R, Hume D, Kennedy D (2005). "Rasputin, more promiscuous than ever: a review of G3BP.". Int. J. Dev. Biol. 48 (10): 1065-77. doi:10.1387/ijdb.041893ki. PMID 15602692.
Onno M, Nakamura T, Hillova J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes.". Oncogene 7 (12): 2519-23. PMID 1461655.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Parker F, Maurier F, Delumeau I, et al. (1996). "A Ras-GTPase-activating protein SH3-domain-binding protein.". Mol. Cell. Biol. 16 (6): 2561-9. PMID 8649363.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Gallouzi IE, Parker F, Chebli K, et al. (1998). "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability.". Mol. Cell. Biol. 18 (7): 3956-65. PMID 9632780.
Costa M, Ochem A, Staub A, Falaschi A (1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway.". Nucleic Acids Res. 27 (3): 817-21. PMID 9889278.
Kociok N, Esser P, Unfried K, et al. (1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells.". J. Cell. Biochem. 74 (2): 194-201. PMID 10404389.
Soncini C, Berdo I, Draetta G (2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.". Oncogene 20 (29): 3869-79. doi:10.1038/sj.onc.1204553. PMID 11439350.
Tourrière H, Gallouzi IE, Chebli K, et al. (2001). "RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization.". Mol. Cell. Biol. 21 (22): 7747-60. doi:10.1128/MCB.21.22.7747-7760.2001. PMID 11604510.
Barnes CJ, Li F, Mandal M, et al. (2002). "Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors.". Cancer Res. 62 (5): 1251-5. PMID 11888885.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tourrière H, Chebli K, Zekri L, et al. (2003). "The RasGAP-associated endoribonuclease G3BP assembles stress granules.". J. Cell Biol. 160 (6): 823-31. doi:10.1083/jcb.200212128. PMID 12642610.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Katsafanas GC, Moss B (2005). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer.". J. Biol. Chem. 279 (50): 52210-7. doi:10.1074/jbc.M411033200. PMID 15471883.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.". Nat. Methods 1 (2): 119-26. doi:10.1038/nmeth715. PMID 15782174.