G-CSF factor stem-loop destabilising element

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G-CSF factor stem-loop destabilising element (SLDE)

Type:	Cis-reg;
2° structure:	Published; PubMed
Seed alignment:	PubMed
Avg length:	94.2 nucleotides
Avg identity:	86%

The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.^[1]

[edit] References

^ Putland, RA; Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ (2002). "RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation". Mol Cell Biol 22: 1664–1673. doi:10.1128/MCB.22.6.1664-1673.2002. PMID 11865046.