FXR2

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Fragile X mental retardation, autosomal homolog 2
Identifiers
Symbol(s) FXR2; FMR1L2
External IDs OMIM: 605339 MGI: 1346074 HomoloGene: 21014
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9513 23879
Ensembl ENSG00000129245 ENSMUSG00000018765
Uniprot P51116 Q6P5B5
Refseq NM_004860 (mRNA)
NP_004851 (protein)		 XM_001006584 (mRNA)
XP_001006584 (protein)
Location Chr 17: 7.44 - 7.46 Mb Chr 11: 69.45 - 69.47 Mb
Pubmed search [1] [2]

Fragile X mental retardation, autosomal homolog 2, also known as FXR2, is a human gene.[1]

The protein encoded by this gene is an RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.[1]

[edit] References

  1. ^ a b Entrez Gene: FXR2 fragile X mental retardation, autosomal homolog 2.

[edit] Further reading

  • Zhang Y, O'Connor JP, Siomi MC, et al. (1996). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.". EMBO J. 14 (21): 5358–66. PMID 7489725. 
  • Siomi MC, Zhang Y, Siomi H, Dreyfuss G (1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.". Mol. Cell. Biol. 16 (7): 3825–32. PMID 8668200. 
  • Tamanini F, Willemsen R, van Unen L, et al. (1997). "Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.". Hum. Mol. Genet. 6 (8): 1315–22. PMID 9259278. 
  • Joseph DR (1998). "The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap.". Steroids 63 (1): 2–4. PMID 9437788. 
  • Tamanini F, Bontekoe C, Bakker CE, et al. (1999). "Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.". Hum. Mol. Genet. 8 (5): 863–9. PMID 10196376. 
  • Bardoni B, Schenck A, Mandel JL (2000). "A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.". Hum. Mol. Genet. 8 (13): 2557–66. PMID 10556305. 
  • Ceman S, Brown V, Warren ST (2000). "Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.". Mol. Cell. Biol. 19 (12): 7925–32. PMID 10567518. 
  • Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53.". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545. 
  • Tamanini F, Kirkpatrick LL, Schonkeren J, et al. (2000). "The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.". Hum. Mol. Genet. 9 (10): 1487–93. PMID 10888599. 
  • Schenck A, Bardoni B, Moro A, et al. (2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMID 11438699. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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