FXC1

From Wikipedia, the free encyclopedia

Fracture callus 1 homolog (rat)

Identifiers

FXC1; TIM10B; TIMM10B; Tim9b

External IDs

OMIM: 607388 MGI: 1315196 HomoloGene: 8142

Gene ontology
Molecular Function:	• zinc ion binding • metal ion binding
Cellular Component:	• mitochondrion • membrane • mitochondrial intermembrane space protein transporter complex
Biological Process:	• cell-matrix adhesion • protein transport • protein import into mitochondrial inner membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012192 (mRNA)
NP_036324 (protein)

NM_019502 (mRNA)
NP_062375 (protein)

Location

Chr 11: 6.46 - 6.46 Mb

n/a

Pubmed search

[1]

[2]

Fracture callus 1 homolog (rat), also known as FXC1, is a human gene.^[1]

FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: FXC1 fracture callus 1 homolog (rat).

[edit] Further reading

Hadjiargyrou M, Halsey MF, Ahrens W, et al. (1998). "Cloning of a novel cDNA expressed during the early stages of fracture healing.". Biochem. Biophys. Res. Commun. 249 (3): 879–84. doi:10.1006/bbrc.1998.9167. PMID 9731230.
Jin H, Kendall E, Freeman TC, et al. (2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins.". Genomics 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.". FEBS Lett. 464 (1-2): 41–7. PMID 10611480.
Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria.". J. Biol. Chem. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.