FUT6

From Wikipedia, the free encyclopedia

Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

Identifiers

FUT6; FLJ40754; FT1A

External IDs

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity • alpha(1,3)-fucosyltransferase activity
Cellular Component:	• extracellular region • Golgi apparatus • membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • L-fucose catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_000150 (mRNA)
NP_000141 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 5.78 - 5.79 Mb

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Pubmed search

[1]

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Fucosyltransferase 6 (alpha (1,3) fucosyltransferase), also known as FUT6, is a human gene.^[1]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase).

[edit] Further reading

Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.". J. Biol. Chem. 267 (34): 24575–84. PMID 1339443.
Koszdin KL, Bowen BR (1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand.". Biochem. Biophys. Res. Commun. 187 (1): 152–7. PMID 1520296.
Cameron HS, Szczepaniak D, Weston BW (1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.". J. Biol. Chem. 270 (34): 20112–22. PMID 7650030.
McCurley RS, Recinos A, Olsen AS, et al. (1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21.". Genomics 26 (1): 142–6. PMID 7782074.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Mollicone R, Reguigne I, Fletcher A, et al. (1994). "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).". J. Biol. Chem. 269 (17): 12662–71. PMID 8175676.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Borsig L, Imbach T, Höchli M, Berger EG (2000). "alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles.". Glycobiology 9 (11): 1273–80. PMID 10536043.
Schnyder-Candrian S, Borsig L, Moser R, Berger EG (2000). "Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369–74. PMID 10900002.
Kamińska J, Musielak M, Nowicka A, et al. (2001). "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase.". Biochimie 83 (8): 739–42. PMID 11530205.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kanoh A, Ota M, Narimatsu H, Irimura T (2003). "Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion.". Biochem. Biophys. Res. Commun. 303 (3): 896–901. PMID 12670495.
Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.". Glycobiology 14 (1): 13–25. doi:10.1093/glycob/cwh006. PMID 14514715.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948.