Fucosylgalactoside 3-alpha-galactosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a fucosylgalactoside 3-alpha-galactosyltransferase (EC 2.4.1.37) is an enzyme that catalyzes the chemical reaction

UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R

Thus, the two substrates of this enzyme are UDP-galactose and [[alpha-L-fucosyl-(1->2)-D-galactosyl-R]], whereas its two products are UDP and [[alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R]].

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase. Other names in common use include UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose, alpha-D-galactosyltransferase, UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, 3-alpha-D-galactosyltransferase, [blood group substance] alpha-galactosyltransferase, blood-group substance B-dependent galactosyltransferase, glycoprotein-fucosylgalactoside alpha-galactosyltransferase, histo-blood group B transferase, and histo-blood substance B-dependent galactosyltransferase. This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1R7U, 1R7X, 1R80, 1R82, 2A8W, 2PGV, and 2PGY.

[edit] References

• IUBMB entry for 2.4.1.37
• BRENDA references for 2.4.1.37 (Recommended.)
• PubMed references for 2.4.1.37
• PubMed Central references for 2.4.1.37
• Google Scholar references for 2.4.1.37
• Race C, Ziderman D and Watkins WM (1968). "An alpha-D-galactosyltransferase associated with the blood-group B character". Biochem. J. 107: 733–735. 

[edit] External links

The CAS registry number for this enzyme class is 37257-33-3.

• IUBMB entry for 2.4.1.37

• KEGG entry for 2.4.1.37

• BRENDA entry for 2.4.1.37

• NiceZyme view of 2.4.1.37

• EC2PDB: PDB structures for 2.4.1.37

• PRIAM entry for 2.4.1.37

• PUMA2 entry for 2.4.1.37

• IntEnz: Integrated Enzyme entry for 2.4.1.37

• MetaCyc entry for 2.4.1.37

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004381: fucosylgalactoside 3-alpha-galactosyltransferase

• AMIGO entry for GO code 0004381: fucosylgalactoside 3-alpha-galactosyltransferase