Fucokinase

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In enzymology, a fucokinase (EC 2.7.1.52) is an enzyme that catalyzes the chemical reaction

ATP + L-fucose $\rightleftharpoons$ ADP + beta-L-fucose 1-phosphate

Thus, the two substrates of this enzyme are ATP and L-fucose, whereas its two products are ADP and beta-L-fucose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:beta-L-fucose 1-phosphotransferase. Other names in common use include fucokinase (phosphorylating), fucose kinase, L-fucose kinase, L-fucokinase, ATP:6-deoxy-L-galactose 1-phosphotransferase, and ATP:L-fucose 1-phosphotransferase. This enzyme participates in fructose and mannose metabolism.

[edit] References

IUBMB entry for 2.7.1.52
BRENDA references for 2.7.1.52 (Recommended.)
PubMed references for 2.7.1.52
PubMed Central references for 2.7.1.52
Google Scholar references for 2.7.1.52
Ishihara H, Massaro DJ, Heath EC (1968). "The metabolism of L-fucose. 3. The enzymatic synthesis of beta-L-fucose 1-phosphate". J. Biol. Chem. 243: 1103–9. PMID 5646161.
Butler W, Serif GS (1985). "Fucokinase, its anomeric specificity and mechanism of phosphate group transfer". Biochim. Biophys. Acta. 829: 238–43. PMID 2986701.
Park SH, Pastuszak I, Drake R, Elbein AD (1998). "Purification to apparent homogeneity and properties of pig kidney L-fucose kinase". J. Biol. Chem. 273: 5685–91. doi:10.1074/jbc.273.10.5685. PMID 9488699.