FSHB

From Wikipedia, the free encyclopedia

Follicle stimulating hormone, beta polypeptide

PDB rendering based on 1fl7.

Available structures: 1fl7, 1xwd

Identifiers

Symbol(s)

FSHB;

External IDs

OMIM: 136530 MGI: 95582 HomoloGene: 430

Gene ontology
Molecular Function:	• follicle-stimulating hormone activity • protein heterodimerization activity
Cellular Component:	• extracellular region • soluble fraction
Biological Process:	• ovarian follicle development • signal transduction • spermatogenesis • female gamete generation • female pregnancy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000510 (mRNA)
NP_000501 (protein)

NM_008045 (mRNA)
NP_032071 (protein)

Location

Chr 11: 30.21 - 30.21 Mb

Chr 2: 106.86 - 106.86 Mb

Pubmed search

[1]

[2]

Follicle stimulating hormone, beta polypeptide, also known as FSHB, is a human gene.^[1]

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide.

[edit] Further reading

Barrios-De-Tomasi J, Timossi C, Merchant H, et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.". Mol. Cell. Endocrinol. 186 (2): 189–98. PMID 11900895.
Saxena BB, Rathnam P (1976). "Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands.". J. Biol. Chem. 251 (4): 993–1005. PMID 1249074.
Keene JL, Matzuk MM, Otani T, et al. (1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells.". J. Biol. Chem. 264 (9): 4769–75. PMID 2494176.
Watkins PC, Eddy R, Beck AK, et al. (1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11.". DNA 6 (3): 205–12. PMID 2885163.
Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids.". Mol. Endocrinol. 2 (9): 806–15. PMID 3139991.
Shome B, Parlow AF, Liu WK, et al. (1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit.". J. Protein Chem. 7 (4): 325–39. PMID 3151250.
Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb).". J. Clin. Endocrinol. Metab. 39 (1): 203–5. PMID 4835136.
Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone.". Biochim. Biophys. Acta 624 (2): 428–35. PMID 6774759.
Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men.". Cell Tissue Res. 278 (3): 595–600. PMID 7850869.
Matthews CH, Borgato S, Beck-Peccoz P, et al. (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.". Nat. Genet. 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432.
Layman LC, Lee EJ, Peak DB, et al. (1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene.". N. Engl. J. Med. 337 (9): 607–11. PMID 9271483.
Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle.". Regul. Pept. 81 (1-3): 67–71. PMID 10395410.
Ben-Menahem D, Hyde R, Pixley M, et al. (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation.". Biochemistry 38 (46): 15070–7. PMID 10563789.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Fox KM, Dias JA, Van Roey P (2001). "Three-dimensional structure of human follicle-stimulating hormone.". Mol. Endocrinol. 15 (3): 378–89. PMID 11222739.
Amoresano A, Orrù S, Siciliano RA, et al. (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain.". Biol. Chem. 382 (6): 961–8. PMID 11501762.
Walton WJ, Nguyen VT, Butnev VY, et al. (2001). "Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit.". J. Clin. Endocrinol. Metab. 86 (8): 3675–85. PMID 11502795.