Fructose-2,6-bisphosphate 2-phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a fructose-2,6-bisphosphate 2-phosphatase (EC 3.1.3.46) is an enzyme that catalyzes the chemical reaction

beta-D-fructose 2,6-bisphosphate + H₂O D-fructose 6-phosphate + phosphate

Thus, the two substrates of this enzyme are beta-D-fructose 2,6-bisphosphate and H₂O, whereas its two products are D-fructose 6-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase. Other names in common use include fructose-2,6-bisphosphatase, and D-fructose-2,6-bisphosphate 2-phosphohydrolase. This enzyme participates in fructose and mannose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1BIF, 1C7Z, 1C80, 1C81, 1FBT, 1K6M, 1TIP, 2AXN, 2BIF, 2DWO, 2DWP, 2I1V, and 3BIF.

[edit] References

• IUBMB entry for 3.1.3.46
• BRENDA references for 3.1.3.46 (Recommended.)
• PubMed references for 3.1.3.46
• PubMed Central references for 3.1.3.46
• Google Scholar references for 3.1.3.46
• van Schaftingen E, Davies DR, Hers HG (1982). "Fructose-2,6-bisphosphatase from rat liver". Eur. J. Biochem. 124: 143–9. doi:10.1111/j.1432-1033.1982.tb05917.x. PMID 6282585. 

[edit] External links

The CAS registry number for this enzyme class is 81611-75-8.

• IUBMB entry for 3.1.3.46

• KEGG entry for 3.1.3.46

• BRENDA entry for 3.1.3.46

• NiceZyme view of 3.1.3.46

• EC2PDB: PDB structures for 3.1.3.46

• PRIAM entry for 3.1.3.46

• PUMA2 entry for 3.1.3.46

• IntEnz: Integrated Enzyme entry for 3.1.3.46

• MetaCyc entry for 3.1.3.46

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004331: fructose-2,6-bisphosphate 2-phosphatase

• AMIGO entry for GO code 0004331: fructose-2,6-bisphosphate 2-phosphatase