FRAT1

From Wikipedia, the free encyclopedia


Frequently rearranged in advanced T-cell lymphomas
PDB rendering based on 1gng.
Available structures: 1gng
Identifiers
Symbol(s) FRAT1;
External IDs OMIM: 602503 MGI: 109450 HomoloGene: 3999
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10023 14296
Ensembl ENSG00000165879 n/a
Uniprot Q92837 n/a
Refseq NM_005479 (mRNA)
NP_005470 (protein)		 NM_008043 (mRNA)
NP_032069 (protein)
Location Chr 10: 99.07 - 99.07 Mb n/a
Pubmed search [1] [2]

Frequently rearranged in advanced T-cell lymphomas, also known as FRAT1, is a human gene.[1]

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.[1]

[edit] References

  1. ^ a b Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas.

[edit] Further reading

  • Jonkers J, Korswagen HC, Acton D, et al. (1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMID 9034327. 
  • Li L, Yuan H, Weaver CD, et al. (1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMID 10428961. 
  • Saitoh T, Katoh M (2001). "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer.". Int. J. Oncol. 19 (2): 311–5. PMID 11445844. 
  • Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.". Structure 9 (12): 1143–52. PMID 11738041. 
  • Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.". Int. J. Oncol. 20 (4): 785–9. PMID 11894125. 
  • Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.". Gene 291 (1-2): 17–27. PMID 12095675. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519. 
  • Khambata-Ford S, Liu Y, Gleason C, et al. (2003). "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay.". Genome Res. 13 (7): 1765–74. doi:10.1101/gr.529803. PMID 12805274. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wang Y, Hewitt SM, Liu S, et al. (2006). "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours.". Br. J. Cancer 94 (5): 686–91. doi:10.1038/sj.bjc.6602988. PMID 16479254. 
  • Hagen T, Cross DA, Culbert AA, et al. (2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.". J. Biol. Chem. 281 (46): 35021–9. doi:10.1074/jbc.M607003200. PMID 16982607. 
 This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.