FMNL1

From Wikipedia, the free encyclopedia

Formin-like 1

Identifiers

FMNL1; C17orf1; C17orf1B; FHOD4; FMNL; KW-13; MGC133052; MGC1894; MGC21878

External IDs

OMIM: 604656 MGI: 1888994 HomoloGene: 55935

Gene ontology
Molecular Function:	• molecular_function • actin binding • Rho GTPase binding
Cellular Component:	• cellular_component
Biological Process:	• biological_process • cellular component organization and biogenesis • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005892 (mRNA)
NP_005883 (protein)

NM_001077698 (mRNA)
NP_001071166 (protein)

Location

Chr 17: 40.66 - 40.68 Mb

Chr 11: 102.99 - 103.01 Mb

Pubmed search

[1]

[2]

Formin-like 1, also known as FMNL1, is a human gene.^[1]

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: FMNL1 formin-like 1.

[edit] Further reading

Kennerson ML, Nassif NT, Nicholson GA (1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat.". Genomics 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
Aronsson FC, Magnusson P, Andersson B, et al. (1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.". Hum. Genet. 103 (3): 340–5. PMID 9799091.
Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.". Mol. Cell. Biol. 20 (18): 6872–81. PMID 10958683.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Katoh M, Katoh M (2003). "Identification and characterization of human DAAM2 gene in silico.". Int. J. Oncol. 22 (4): 915–20. PMID 12632087.
Katoh M, Katoh M (2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico.". Int. J. Oncol. 22 (5): 1161–8. PMID 12684686.
Favaro PM, de Souza Medina S, Traina F, et al. (2004). "Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt.". Biochem. Biophys. Res. Commun. 311 (2): 365–71. PMID 14592423.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.