FLT3LG

From Wikipedia, the free encyclopedia

Fms-related tyrosine kinase 3 ligand

PDB rendering based on 1ete.

Available structures: 1ete

Identifiers

Symbol(s)

FLT3LG;

External IDs

OMIM: 600007 MGI: 95560 HomoloGene: 48021

Gene ontology
Molecular Function:	• cytokine activity
Cellular Component:	• extracellular space • soluble fraction • membrane • integral to membrane
Biological Process:	• signal transduction • positive regulation of cell proliferation • lymphocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001459 (mRNA)
NP_001450 (protein)

NM_013520 (mRNA)
NP_038548 (protein)

Location

Chr 19: 54.67 - 54.68 Mb

Chr 7: 45 - 45 Mb

Pubmed search

[1]

[2]

Fms-related tyrosine kinase 3 ligand, also known as FLT3LG, is a human gene.^[1]

[edit] References

^ Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand.

[edit] Further reading

Lyman SD, James L, Vanden Bos T, et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells.". Cell 75 (6): 1157–67. PMID 7505204.
Lyman SD, Stocking K, Davison B, et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci.". Oncogene 11 (6): 1165–72. PMID 7566977.
Lyman SD, James L, Escobar S, et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs.". Oncogene 10 (1): 149–57. PMID 7824267.
Hannum C, Culpepper J, Campbell D, et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851.
Lyman SD, James L, Johnson L, et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells.". Blood 83 (10): 2795–801. PMID 8180375.
Slanicka Krieger M, Nissen C, Manz CY, et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow.". Exp. Hematol. 26 (5): 365–73. PMID 9590652.
Graddis TJ, Brasel K, Friend D, et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen.". J. Biol. Chem. 273 (28): 17626–33. PMID 9651358.
Solanilla A, Grosset C, Lemercier C, et al. (2000). "Expression of Flt3-ligand by the endothelial cell.". Leukemia 14 (1): 153–62. PMID 10637491.
Savvides SN, Boone T, Andrew Karplus P (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197.
Chklovskaia E, Nissen C, Landmann L, et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A.". Blood 97 (4): 1027–34. PMID 11159533.
Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE (2002). "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model.". Int. Immunopharmacol. 1 (12): 2081–9. PMID 11710537.
Li H, Cai Y, Xu J (2002). "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi 20 (6): 285–7. PMID 11721383.
Feugier P, Jo DY, Shieh JH, et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand.". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009.
O'Keeffe M, Hochrein H, Vremec D, et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice.". Blood 99 (6): 2122–30. PMID 11877288.
Retzlaff S, Padró T, Koch P, et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma.". Oncol. Rep. 9 (3): 525–7. PMID 11956621.
Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V, et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells.". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110.
Vávrová J, Vokurková D, Mareková M, et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells.". Folia Biol. (Praha) 48 (2): 51–7. PMID 12002675.
Testa U, Torelli GF, Riccioni R, et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors.". Blood 99 (12): 4634–7. PMID 12036900.
Mosca PJ, Hobeika AC, Colling K, et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.". J. Leukoc. Biol. 72 (3): 546–53. PMID 12223523.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.