FLRT2

From Wikipedia, the free encyclopedia

Fibronectin leucine rich transmembrane protein 2

Identifiers

FLRT2; KIAA0405

External IDs

OMIM: 604807 MGI: 3603594 HomoloGene: 8291

Gene ontology
Molecular Function:	• receptor signaling protein activity • protein binding, bridging
Cellular Component:	• proteinaceous extracellular matrix • integral to plasma membrane • membrane
Biological Process:	• cell adhesion • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_013231 (mRNA)
NP_037363 (protein)

NM_201518 (mRNA)
NP_958926 (protein)

Location

Chr 14: 85.07 - 85.16 Mb

Chr 12: 96.09 - 96.18 Mb

Pubmed search

[1]

[2]

Fibronectin leucine rich transmembrane protein 2, also known as FLRT2, is a human gene.^[1]

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.^[1]

[edit] References

^ ^a ^b Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (2000). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.". Genomics 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID 10644439.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.