FLOT2

From Wikipedia, the free encyclopedia

Flotillin 2

PDB rendering based on 1win.

Available structures: 1win

Identifiers

Symbol(s)

FLOT2; ECS-1; ECS1; ESA; ESA1; M17S1

External IDs

OMIM: 131560 MGI: 103309 HomoloGene: 3293

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• plasma membrane • cell surface • integral to membrane • flotillin complex • lipid raft
Biological Process:	• cell adhesion • epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004475 (mRNA)
NP_004466 (protein)

NM_001040403 (mRNA)
NP_001035493 (protein)

Location

Chr 17: 24.23 - 24.25 Mb

Chr 11: 77.85 - 77.88 Mb

Pubmed search

[1]

[2]

Flotillin 2, also known as FLOT2, is a human gene.^[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.^[1]

[edit] References

^ ^a ^b Entrez Gene: FLOT2 flotillin 2.

[edit] Further reading

Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M (1992). "The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12.". Genomics 11 (2): 481-2. PMID 1769667.
Schroeder WT, Stewart-Galetka S, Mandavilli S, et al. (1994). "Cloning and characterization of a novel epidermal cell surface antigen (ESA).". J. Biol. Chem. 269 (31): 19983-91. PMID 8051082.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.". J. Biol. Chem. 274 (18): 12702-9. PMID 10212252.
Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.". J. Cell. Biochem. 75 (1): 147-59. PMID 10462713.
Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.". Blood 97 (4): 1141-3. PMID 11159550.
Solomon S, Masilamani M, Rajendran L, et al. (2002). "The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs.". Immunobiology 205 (1): 108-19. PMID 11999340.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607-16. doi:10.1074/jbc.M210455200. PMID 12493773.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hazarika P, McCarty MF, Prieto VG, et al. (2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.". Cancer Res. 64 (20): 7361-9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Bracho C, Dunia I, Romano M, et al. (2006). "Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax.". Parasitol. Res. 99 (2): 153-9. doi:10.1007/s00436-006-0139-6. PMID 16521037.
Doherty SD, Prieto VG, George S, et al. (2007). "High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma.". Melanoma Res. 16 (5): 461-3. doi:10.1097/01.cmr.0000222592.75858.20. PMID 17013097.
Jiang M, Ding Y, Su Y, et al. (2007). "Arginase-flotillin interaction brings arginase to red blood cell membrane.". FEBS Lett. 580 (28-29): 6561-4. doi:10.1016/j.febslet.2006.11.003. PMID 17113085.
Sugawara Y, Nishii H, Takahashi T, et al. (2007). "The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase.". Cell. Signal. 19 (6): 1301-8. doi:10.1016/j.cellsig.2007.01.012. PMID 17307333.
Langhorst MF, Solis GP, Hannbeck S, et al. (2007). "Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin.". FEBS Lett. 581 (24): 4697-703. doi:10.1016/j.febslet.2007.08.074. PMID 17854803.