Flavonol synthase

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In enzymology, a flavonol synthase (EC 1.14.11.23) is an enzyme that catalyzes the chemical reaction

a dihydroflavonol + 2-oxoglutarate + O₂ $\rightleftharpoons$ a flavonol + succinate + CO₂ + H₂O

The 3 substrates of this enzyme are dihydroflavonol, 2-oxoglutarate, and O₂, whereas its 4 products are flavonol, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase. This enzyme participates in flavonoid biosynthesis.

[edit] References

IUBMB entry for 1.14.11.23
BRENDA references for 1.14.11.23 (Recommended.)
PubMed references for 1.14.11.23
PubMed Central references for 1.14.11.23
Google Scholar references for 1.14.11.23
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Lukacin R, Wellmann F, Britsch L, Martens S, Matern U (2003). "Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase". Phytochemistry. 62: 287–92. doi:10.1016/S0031-9422(02)00567-8. PMID 12620339.
Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R (2003). "Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley". FEBS. Lett. 544: 93–8. doi:10.1016/S0014-5793(03)00479-4. PMID 12782296.
CJ (2004). "Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase". J. Biol. Chem. 279: 1206–16. doi:10.1074/jbc.M309228200. PMID 14570878.