Flavone synthase

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In enzymology, a flavone synthase (EC 1.14.11.22) is an enzyme that catalyzes the chemical reaction

a flavanone + 2-oxoglutarate + O₂ $\rightleftharpoons$ a flavone + succinate + CO₂ + H₂O

The 3 substrates of this enzyme are flavanone, 2-oxoglutarate, and O₂, whereas its 4 products are flavone, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating). This enzyme participates in flavonoid biosynthesis and isoflavonoid biosynthesis.

[edit] References

IUBMB entry for 1.14.11.22
BRENDA references for 1.14.11.22 (Recommended.)
PubMed references for 1.14.11.22
PubMed Central references for 1.14.11.22
Google Scholar references for 1.14.11.22
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G, Martens S (2001). "Purification and antigenicity of flavone synthase I from irradiated parsley cells". Arch. Biochem. Biophys. 393: 177–83. doi:10.1006/abbi.2001.2491. PMID 11516175.
Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R (2003). "Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley". FEBS. Lett. 544: 93–8. doi:10.1016/S0014-5793(03)00479-4. PMID 12782296.