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| Flavivirus 3' UTR cis-acting replication element (CRE) |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed; Bateman A, Moxon SJ, Weinberg Z |
| Seed alignment: |
Bateman A, Moxon SJ, Weinberg Z |
| Avg length: |
95.4 nucleotides |
| Avg identity: |
69% |
|
The Flavivirus 3' UTR cis-acting replication element (CRE) is an RNA element that is thought to play a crucial role in replication and is thought to be needed for the formation of a "replication complex".[1] Although evidence has been presented for an existence of a pseudoknot structure in this RNA,[2] it does not appear to be well conserved across flaviviruses. Deletions of the 3' UTR of flaviviruses have been shown to be lethal for infectious clones.
[edit] References
- ^ Zeng, L; Falgout B, Markoff L (1998). "Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replication". J Virol 72: 7510–7522. PMID 9696848.
- ^ Shi, PY; Brinton MA, Veal JM, Zhong YY, Wilson WD (1996). "Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA". Biochemistry 35: 4222–4230. doi:10.1021/bi952398v. PMID 8672458.
[edit] External links
