FKBP8

From Wikipedia, the free encyclopedia

FK506 binding protein 8, 38kDa

PDB rendering based on 2awg.

Available structures: 2awg, 2d9f, 2f2d

Identifiers

Symbol(s)

FKBP8; FKBP38; FKBPr38

External IDs

OMIM: 604840 MGI: 1341070 HomoloGene: 7720

Gene ontology
Molecular Function:	• binding
Cellular Component:	• mitochondrial envelope • integral to endoplasmic reticulum membrane
Biological Process:	• cell fate specification • protein folding • smoothened signaling pathway • intracellular signaling cascade • dorsal/ventral pattern formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012181 (mRNA)
NP_036313 (protein)

NM_010223 (mRNA)
NP_034353 (protein)

Location

Chr 19: 18.5 - 18.52 Mb

Chr 8: 73.46 - 73.46 Mb

Pubmed search

[1]

[2]

FK506 binding protein 8, 38kDa, also known as FKBP8, is a human gene.^[1]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.^[1]

[edit] References

^ ^a ^b Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa.

[edit] Further reading

Lam E, Martin M, Wiederrecht G (1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.". Gene 160 (2): 297-302. PMID 7543869.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Pedersen KM, Finsen B, Celis JE, Jensen NA (1999). "muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo.". Electrophoresis 20 (2): 249-55. doi:10.1002/(SICI)1522-2683(19990201)20:2<249::AID-ELPS249>3.0.CO;2-F. PMID 10197430.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Shirane M, Nakayama KI (2003). "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.". Nat. Cell Biol. 5 (1): 28-37. doi:10.1038/ncb894. PMID 12510191.
Rosner M, Hofer K, Kubista M, Hengstschläger M (2003). "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38.". Oncogene 22 (31): 4786-98. doi:10.1038/sj.onc.1206776. PMID 12894220.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Bulgakov OV, Eggenschwiler JT, Hong DH, et al. (2004). "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.". Development 131 (9): 2149-59. doi:10.1242/dev.01122. PMID 15105374.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Kang CB, Tai J, Chia J, Yoon HS (2005). "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).". FEBS Lett. 579 (6): 1469-76. doi:10.1016/j.febslet.2005.01.053. PMID 15733859.
Weiwad M, Edlich F, Erdmann F, et al. (2005). "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.". FEBS Lett. 579 (7): 1591-6. doi:10.1016/j.febslet.2004.12.098. PMID 15757646.
Edlich F, Weiwad M, Erdmann F, et al. (2005). "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.". EMBO J. 24 (14): 2688-99. doi:10.1038/sj.emboj.7600739. PMID 15990872.
Kang CB, Feng L, Chia J, Yoon HS (2005). "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2.". Biochem. Biophys. Res. Commun. 337 (1): 30-8. doi:10.1016/j.bbrc.2005.09.023. PMID 16176796.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.