Talk:Fipronil
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Article Grading: The following comments were left by the quality and importance raters: (edit · refresh) Undid edit by 76.25.72.130 due to lack of quotable reference and slander against Wikipedia. Comment claimed article content was in error though article's content can easily be validated via cross-reference against multiple reputable sites covering the subject. |
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[edit] Symptoms of fipronil poisoning
"In humans, fipronil poisoning is characterized by vomiting, agitation, and seizures, and can usually be managed through supportive care and early treatment of seizures.[2] This risk may be associated with the withdrawal of the MaxForce tick management product."
I can't see how the risk of generalised symptoms of fipronil poisoning should be associated with withdrawal of a proprietary product, and have removed the second sentence. Please let me know if/where my logic is wrong. In any even the paragraph seems to need rewriting. Davy p 00:06, 4 November 2007 (UTC)
- The Maxforce tick management system (TMS) was removed from general use in 2005 because there were reports of grey squirrels chewing into some Maxforce TMS boxes in areas of the Northeastern United States which compromised the integrity of the child resistant box. Due to this problem, the Federal Environmental Protection Agency (EPA) has removed the plastic TMS boxes from distribution and has asked that those already in use be covered with a protective metal shroud capable of preventing squirrel damage. Bugguyak 15:18, 4 November 2007 (UTC)
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- Thanks. But I still don't quite see how this aspect follows from a description of the symptoms of poisoning. Shouldn't the two points (symptoms of poisoning + problems with squirrels) go in separate paragraphs or sections? The symptoms of fipronil poisoning won't be changed (even if the incidence might possibly be reducced) by the withdrawal of plastic TMS boxes. Davy p 20:09, 4 November 2007 (UTC)
[edit] need expert to compact and clarify
at top of article: "blocking the passage of chloride ions through the GABA receptor and glutamate receptor (GluCl), components of the central nervous system. This causes hyperexcitation of contaminated insects' nerves and muscles. Insect specificity of fipronil may come from a better efficacy on GABA receptor but also on the fact that GluCl does not exist in mammals.[1]"
and later, different author wrote: It acts by binding to an allosteric site of GABAA receptors and GluCl receptor (of the insect), a form of non-competitive inhibition.
too many cooks on Wikipedia, as usual —Preceding unsigned comment added by 74.170.68.234 (talk) 14:42, 26 May 2008 (UTC)
