FCGR1A

From Wikipedia, the free encyclopedia

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Identifiers

FCGR1A; CD64; CD64A; FCRI; IGFR1

External IDs

Gene ontology
Molecular Function:	• receptor activity • receptor signaling protein activity • IgG binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• phagocytosis, engulfment • immune response • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000566 (mRNA)
NP_000557 (protein)

NM_010186 (mRNA)
NP_034316 (protein)

Location

Chr 1: 148.02 - 148.03 Mb

Chr 3: 96.37 - 96.38 Mb

Pubmed search

[1]

[2]

Fc fragment of IgG, high affinity Ia, receptor (CD64), also known as FCGR1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64).

[edit] Further reading

Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors.". Annu. Rev. Immunol. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.". J. Biol. Chem. 267 (22): 15692–700. PMID 1379234.
Benech PD, Sastry K, Iyer RR, et al. (1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.". J. Exp. Med. 176 (4): 1115–23. PMID 1402657.
Porges AJ, Redecha PB, Doebele R, et al. (1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells.". J. Clin. Invest. 90 (5): 2102–9. PMID 1430234.
van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene.". J. Biol. Chem. 266 (20): 13449–55. PMID 1830050.
Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts.". Intervirology 29 (6): 339–45. PMID 2852656.
Allen JM, Seed B (1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs.". Science 243 (4889): 378–81. PMID 2911749.
Allen JM, Seed B (1989). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).". Nucleic Acids Res. 16 (24): 11824. PMID 2974947.
Indik ZK, Hunter S, Huang MM, et al. (1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.". Exp. Hematol. 22 (7): 599–606. PMID 7516890.
Valerius T, Repp R, de Wit TP, et al. (1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy.". Blood 82 (3): 931–9. PMID 7687898.
Wang AV, Scholl PR, Geha RS (1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.". J. Exp. Med. 180 (3): 1165–70. PMID 8064233.
Takai S, Kasama M, Yamada K, et al. (1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization.". Hum. Genet. 93 (1): 13–5. PMID 8270248.
Morton HC, van den Herik-Oudijk IE, Vossebeld P, et al. (1996). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association.". J. Biol. Chem. 270 (50): 29781–7. PMID 8530370.
Maresco DL, Chang E, Theil KS, et al. (1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21.". Cytogenet. Cell Genet. 73 (3): 157–63. PMID 8697799.
De SK, Venkateshan CN, Seth P, et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood 91 (6): 2108–17. PMID 9490697.
Maresco DL, Blue LE, Culley LL, et al. (1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1.". Cytogenet. Cell Genet. 82 (1-2): 71–4. PMID 9763663.
Kyono WT, de Jong R, Park RK, et al. (1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).". J. Immunol. 161 (10): 5555–63. PMID 9820532.
Fanger NA, Cosman D, Peterson L, et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.". Eur. J. Immunol. 28 (11): 3423–34. PMID 9842885.
Gorgani NN, Altin JG, Parish CR (1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes.". Int. Immunol. 11 (8): 1275–82. PMID 10421785.
Tridandapani S, Lyden TW, Smith JL, et al. (2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.". J. Biol. Chem. 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.